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When one is immersed in the fascinating world of neuroscience findings, the brain might start to seem like a collection of "modules," each specializes in a specific mental feat. But just like in other domains of Nature, it is possible that much of the brain and mind's operation can be explained with a small set of universal principles. Given exciting recent developments in theory, empirical findings and computational studies, it seems that the generation of predictions might be one strong candidate for such a universal principle. This is the focus of Predictions in the brain. From the predictions required when a rat navigates a maze to food-caching in scrub-jays; from predictions essential in decision-making to social interactions; from predictions in the retina to the prefrontal cortex; and from predictions in early development to foresight in non-humans. The perspectives represented in this collection span a spectrum from the cellular underpinnings to the computational principles underlying future-related mental processes, and from systems neuroscience to cognition and emotion. In spite of this diversity, they share some core elements. Memory, for instance, is critical in any framework that explains predictions. In asking