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In recent years the detection of pharmaceuticals within the natural environment has led to concern from many parties and a growing recognition of both their levels and their real or potential environmental impact. The life-cycle of pharmaceuticals in the environment identifies pathways of entry of pharmaceuticals into the environment - beginning with the role of global prescribing and disposal practices. It then discusses typical levels of common pharmaceuticals and how they can be determined in natural waters such as raw and treated sewage, and potable water. Methods currently available to degrade pharmaceuticals in the natural waters are discussed and then some of their ecotoxicological impacts are reviewed. Future considerations and the growing concept of 'product stewardship' are also examined.